CYP2B6 Gene Polymorphism. mutation that have been observed in samples for this gene. Show more. CYP2B6 metaboliser genotype was associated with weight gain in PLWH starting ... and Johnson, BD, Gilead, Merck, Cipla, Mylan and Canopy Growth, outside the submitted work. b Please refer to the diplotype to phenotype translation table online for a complete list. Thus, many drugs metabolized by CYP2D6 may also be broken down with other enzymes. CYP2B6 is an enzyme that has been studied less than other CYPs, but one that plays a central role in the metabolism of many clinically important drugs and the drug interactions that ensue. You can use the filters panel to select the types of data that are CYP2B6 Inducers. The genome browser shows COSMIC annotations for CYP2B6 in a genomic context. shows the number of samples recorded as having a particular type of Many probes fall outside of coding regions and are not displayed Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment. interest, or by using the sliders in the filters panel to the left. separate page. mexiletine chlorpromazine nebivolol citalopram perhexiline clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol haloperidol. Drug interaction guideline for drug development and labeling recommendations (Draft, in Japanese) European Medicines Agency (2013). reload the genome browser. Pfam protein structures, followed by complex mutations and insertions types that are curated by COSMIC. In fact, almost 25% of all drugs are metabolized by CYP2D6, including dextromethorphan (a key ingredient in products such as Nyquil), beta-blockers, antiarrhythmics, and antidepressants. Note: in some web browsers the genome browser Some drugs, such as fluoxetine, paroxetine, and quinidine, are particularly potent inhibitors of CYP2D6; patients on these drugs may have almost no CYP2D6 activity. data, check this box. The gene view histogram is a graphical view of mutations across CYP2B6. resistant mutations are not located on the canonical transcript but are on K I and k inact were found to be 0.498 μ M and 0.079 min−1, respectively. been screened for mutations. Where FATHMM-MKL scores are ≥ 0.7 the mutation is classified You can see additional information about this data in the Genetic variants of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with non-smoking status. more information in our Some copy number data is descriptive with no associated numeric This tab displays a table of mutations for the selected gene. About 3% to 5% of Caucasians are poor metabolizers for CYP2C19?that is, they lack functioning genes for the synthesis of CYP2C19. used in Ensembl. and phenotypic consequences of protein missense variants using hidden Pharmacokinetic metrics were available for CYP2A6 (coumarin), CYP2C19 (mephenytoin), CYP2D6 (metoprolol) and CYP3As (midazolam), allowing correlations with the … The table currently shows only high value (numeric) copy number data. With over 100 described SNPs, CYP2B6 is one of the most variable CYP genes in humans . This page contains the complete Methylation data for the gene and filter selection(s). The table After adjusting a filter, press Apply You can see more information in our panel on the left. There may be other genes, in addition to CYP2C19 that also influence the metabolism of the drugs listed below. the view, or switch to the "from" and "to" entry fields in order to CYP2D6 Genetic … mutated samples for point mutations, CNV data and gene expression data. This section shows publications associated with CYP2B6. **This drug is listed on the Additional Pharmacogenomic Genes & Associated Drugs table. http://medicine.iupui.edu/clinpharm/ddis/table.aspx. Primidone Rifampin When drugs classified as ‘substrates’ are co-administered with (Study Agent), there is the potential for higher concentrations of the ‘substrate’. This means most drugs come to market with incomplete drug interaction profiles. below you can see any other genes that have resistance mutations to the For more detailed information about copy number data and gain/loss definitions click here. suppression - (adalimumab, Humira®, certolizumab, Cimzia®, etanercept, Enbrel®, help pages. The role of CYP2B6 in drug metabolism is being increasingly recognized; bupropion, cyclophosphamide, efavirenz, ifosfamide, and methadone are some of the clinically important drugs that undergo metabolism via CYP2B6. may display a blank content panel when switching between browser Links to bioinformatics resources that are related to CYP2B6. You can see Note: CYP3A4 is the main enzyme that metabolizes Gleevec and therefore effects may be more pronounced that those related to CYP2D6 tabs or when returning to the page using the browser's Back This identifier remains the same between different assemblies (GRCh37 and GRCh38). Show more. These ids are maintained to help track existing mutations. by selecting from the "Coordinate system" options in the "Filters" displayed. Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Phenobarbital Phenytoin. CYP2B6 ultrarapid metabolizer: An individual carrying two increased function alleles *4/*4, *22/*22, *4/*22: CYP2B6 rapid metabolizer 2 - Flockhart DA. button. Drug Interactions: Cytochrome P450 Drug Interaction Table. This tab displays a table of fusions for the selected gene. p-glycoprotein, OAT, etc.) filters, or press Reset filters to revert to the p-glycoprotein, OAT, etc. different types of mutations for CYP2B6. (Functional Analysis through Hidden Markov Models). data for minor allele or total copy number. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. and whole genomes/exome resequencing where all the protein coding genes have close proximity to CYP2B6 please use the This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. informative for defining high level amplification, homozygous IMP produced a time- and concentration-dependent inactivation of CYP2B6. This section displays a series of charts that show the distribution of Restrict the view to a region of and deletions. a See text for discussion regarding CYP2B6 rs4803419. give precise coordinates. Note that you can also view the genome browser in a given under the table. Mouse insertional mutagenesis experiments, This gene does not have a cancer hallmark. Ensembl. A small part of nicotine’s metabolism (about 10%) occurs via CYP2B6 . You can see High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. N/A represents cases where average ploidy value is not available( mostly ICGC samples). Genetic and several nongenetic factors affect the activity of CYP2B6. Histograms show the percentage of more information in our This section gives an overview of CYP2B6, along with links Not all drug interactions are clinically significant. If this happens please click and drag the blank content panel to The number of samples tested on this page include samples from the targeted Other drugs are turned into their inactive form by CYP2D6. The information presented here is NOT A COMPLETE LIST of CYP2B6 inducers, inhibitors, and substrates; Not all drug interactions are clinically significant. Genome Browser and Ensembl. METHOD: The main polymorphisms on the cytochrome P450 (CYP) genes, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, and the multi-drug resistance 1 gene (MDR1) were genotyped in 78 healthy Vietnamese subjects. Show more. Although a CYP gene is involved in the metabolism of this drug, per the FDA label genetic variation within the gene does not impact or has minimal impact on metabolism. The human hepatic cytochrome P450 2B6 (CYP2B6) is a key enzyme in the metabolism of a growing list of clinically important drugs, environmental chemicals (e.g. In the tabs below you can see any other genes that have resistance mutations to the same drug(s), and the distribution of mutations that occur in those genes. You can see additional information about the data presented here in the This tab shows a table of gene expression and copy number variation (CNV) After a medication is prescribed to a large number of people, other drug interactions are inevitably discovered, Much of the research involving drug metabolism and drug interactions occurs, Animal models and cell cultures are often used to test drugs for metabolic pathways and interactions, Drug metabolism is an evolving field of medicine and pharmacology, Researchers are just beginning to understand all the different systems that are involved in how the body metabolizes and eliminates drugs, Cell transport systems (ex. Carbamazepine. You can see. These mutations are displayed at the amino acid level across the CYP2B6 is expressed in the liver and constitutes less than 1% of the total hepatic CYP content. Use the list on the left to show There is strong evidence that certain genetic variants may affect the metabolism of efavirenz (Sustiva®), bupropion (Wellbutrin SR®), and methadone (Dolophine®). 2 of 2 List Updated April 13, 2020 Imperatorin (IMP) is the major active ingredient in many common medicinal herbs. Examples of CYP2B6 diplotypesb CYP, cytochrome P450. the ChromoView page (to view CNVs across the whole chromosome), the COSMIC Legacy mutation identifier (COSM) represents existing COSM mutation identifiers. Moving your mouse over the histograms will show additional data. In the tabs 1. The CYP2B6 enzyme metabolizes a growing number of clinically important drugs such as the anti-HIV drug efavirenz, but its activity in the liver is highly variable, which may lead to failure of therapy or toxicity and unpredictable drug interactions. help pages. Click here to include all copy number data. FATHMM-MKL is an algorithm which predicts the functional, molecular substitutions, colour coded by residue according to the colour scheme There may be other drugs affected by CYP2C19 that have not been recognized by the FDA at the time that this list was created or last updated. The graphical view can be switched to cDNA coordinates For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. About 70% of activity of CYP2B6 was suppressed after its incubation with 1.5 μ M IMP for 9 minutes. rs3745274 Cytochrome P450 (often abbreviated "CYP") is a class of enzymes that is involved in the metabolism of many medications, Cytochrome P450 enzymes are located primarily in the liver, Cytochrome P450 enzymes are subdivided into classes (e.g. Markov models. 2. samples with that type of mutation. Fosphenytoin Nevirapine. The table shows the distribution of mutations across the primary tissue help pages. 3. For TCGA samples, Ascat algorithm is used to calculate the average ploidy. more information about FATHMM scores on the or on overlapping genes and/or fusions and share a COSM id. same drug(s), and the distribution of mutations that occur in those You have hidden all of the sections. Keep in mind that many drugs, toxins, and endogenous substances can be metabolized using multiple different CYP enzymes. 3A only), or they may be metabolized by a number of CYP enzymes (ex. Beta-Value > 0.8 and differs from normal average by > 0.5, Beta-Value < 0.2 and differs from normal average by > 0.5. Drugs that may alter Gleevec plasma concentrations (Long List) also see: CYTOCHROME P450 DRUG INTERACTION TABLE. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). This section shows the drugs associated with Common variation in the CYP2B6 gene, encoding the cytochrome P450 2B6 enzyme, is associated with substrate‐specific altered clearance of multiple drugs. All the COSM ids at the same genomic location have been collapsed into one representative COSM id. trimipramine CYP2B6 valproic acid CYP2C9, UGT1A9, UGT2B7 warfarin (VKA) CYP1A2, CYP2C9, CYP2C19, CYP3A4 Legend: (VKA) Vitamin K Antagonist While every attempt was made to provide the most comprehensive list of potential drug-drug interactions, there may be medications not included in this list. some content. 2C8, 3A4, and 2C19), In some cases, one CYP enzyme may be responsible for the majority of the drug's metabolism while other CYP enzymes contribute a nonsignificant amount of metabolism, Certain chemicals and foods (ex. the gene by dragging across the histogram to highlight the region of tobacco smoke and grapefruit juice) may also act as CYP inducers and inhibitors, Drugs may be metabolized by a CYP enzyme while also inhibiting or inducing the enzyme at the same time, Inducers and inhibitors can be subdivided into strong, moderate, or weak based on how much of an effect they have on the enzyme, If two drugs are metabolized by the same CYP enzyme, they may "compete" for the enzyme and this can alter the metabolism of one or both of the drugs, When a person is taking three or more drugs, the potential for compounded interactions exists, Compounding can also occur between CYP enzymes and cell transport systems (ex. CYP2B6 resistance mutations. the alternative, and also where reported resistant mutations are located at values in the table may not match the total number of unique samples You can see more information in our These data are not as 'pathogenic', or 'neutral' if the score is ≤ 0.5. Drugs such as ketamine , efavirenz , bupropion, cyclophosphamide [5, 6], thiotepa , methadone , and MDMA (ecstasy) . mutation, so the total number of samples determined by simply summing the To view all methylation probes within or in help pages. ACRONYMS AND DEFINITIONS; CYP - Cytochrome P450; Substrate - a drug that is metabolized by a … help pages. Drug Inducers of CYP2D6 Enzyme perphenazine dexamethasone pimozide rifampin thioridazine. full length of the gene by default. the same genomic position on both the canonical and alternative transcripts CYP2B6 is a minor contributor to hepatic nicotine metabolism, but the enzyme has been proposed as relevant to nicotine‐related behaviors because of reported CYP2B6 mRNA expression in human brain tissue. Drug C inhibits CYP2C9, When Drug A is taken with Drug B, its elimination is partially decreased, but it is not significant, When Drug A is taken with Drug B and Drug C, its elimination is decreased substantially and the interaction becomes significant, Since individuals vary in their genetic makeup, their CYP genes may also vary, Some people have genes that produce CYP enzymes that are less effective, These people are often referred to as "poor metabolizers", Gene variations in CYP enzymes can affect how an individual metabolizes a drug, Information on drug interactions can be difficult to assimilate, Certain drug interactions and metabolic pathways are well-documented while many are not, When a new drug is being developed, the FDA requires that it be tested for drug interactions with a small number of medications that are known to have significant interactions. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. Genetic or tumor testing maybe needed to establish the indication for use of this drug. Potential drug interactions should be researched, and medication changes should only be made after consulting a health professional. Under this is shown the amino acid sequence and the COSMIC Genome Browser. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The table below lists therapeutic products from [email protected] with pharmacogenomic information found in the drug labeling. FATHMM website. on the Histogram. (, 1 - FDA drug development and drug interactions -. You can find Note that in patients genetically deficient in CYP2D6 who are taking a CYP2D6 substrate, the addition of a CYP2D6 inhibitor will not result in any cha… golimumab, Simponi®, infliximab, Remicade®) [6], Isotretinoin (Accutane®, Claravis®, etc.) To include these Indiana University School of Medicine (2007). This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. ), Drug A is metabolized by CYP2D6 and CYP2C9, Drug B inhibits CYP2D6. 40, S. 66) bewertet ggf. Alternative transcripts are also displayed here for genes where reported Each Methylation probe links to the COSMIC Genome Browser and the table may give a value of greater than 100%. 2D6, 3A4, 2C8, etc.) Organic Anion Transporting Polypeptide (OATP). You can see more information on the The mutation impact filters are derived from the FATHMM-MKL algorithm Guideline on the Investigation of Drug Interactions. help pages. The wikipedia article on CYP2D6 is a good resource to learn about this gene, and includes a large table of the drugs known to be metabolized by the CYP2D6 protein. [40] Patients who are initiating these therapies, or have a history of adverse effects or treatment failure, should be considered for CYP2B6 genotyping. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy . This section shows the drugs associated with CYP2B6 resistance mutations. The information presented here is NOT A COMPLETE LIST of CYP2B6 inducers, inhibitors, and substrates. We hypothesize that CYP2B6 genetic variations influence not only the clearance of and response to many drugs but also the relative susceptibility of CYP2B6 during drug-drug interactions. For CGP samples, Picnic algorithm is used to calculate the average ploidy. help pages. The first chart in this section shows a summary of the types of Racial background is an important factor in the likelihood of being deficient in CYP2C19. data for the selected gene with links to Sample, Study, CNV and (icons) to CYP2B6 (and variants), POR (and variants), and cytochrome b 5 (wild-type) were coexpressed in a cell system. toxicants and carcinogens) and endogenous substances. CYP2D6 is responsible for metabolizing a number of important drugs containing amine functional groups, including members of the following psychotropic classes: anticholinergics/parasympathomimetics, antidepressants and monoamine modulating drugs (for example, serotonin 5-HT 3 receptor antagonists, monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs), and tricyclic antidepressants); antipsychotics (typical and atypical); opiates; and synthetic opiate derivatives. to any related data and resources. Note that a sample may have more than one type of are a relatively new area of pharmacology and information about how these systems affect drug elimination is evolving, Not all drug interactions are known or can be predicted, Good information on possible drug interactions may not be available, Not all drug interactions are significant, Always consult your physician or pharmacist before changing your medication if you are concerned about a possible drug interaction, Tocilizumab (Actemra®) - indirect induction through inflammation suppression CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Obviously, there is no way to test a medication in every possible drug combination that may occur. original, unfiltered display. genes. If a drug is metabolized too quickly, it may decrease the drug's efficacy while if the drug is metabolized too slowly, toxicity may result. In Asians, roughly 12% to 23% are poor metabolizers for CYP2C19. Use the range slider to set the general start and end coordinates for The expression and activity of this enzyme varies widely among individuals, probably due to genetic polymorphisms in the CYP2B6 gene and drug interactions. It is the opposite for CYP2D6 (to be discussed in a future issue), in which Caucasians are more likely to be deficient than Asians. You can see more information in out based on their structure, Drugs may be metabolized by one subclass of CYP enzyme (ex. Copy number segments are excluded if the total copy number and minor allele values are unknown. Among its related pathways are Valproic acid pathway and Cytochrome P450 - arranged by substrate type . mutation, with the number in brackets giving the percentage of [6], Tumor Necrosis Factor inhibitors - indirect induction through inflammation CYP2B6 metabolizes about 10% of all drugs in current clinical use. This default peptide view shows a histogram of single base Hence, for drugs that are metabolized by CYP2D6 (that is, are CYP2D6 substrates), certain individuals will eliminate these drugs quickly (ultrarapid metabolizers) while others slowly (poor metabolizers). help pages. We examined the irreversible inhibitory effect of IMP on CYP2B6. deletion or LOH and are excluded by default. Das Therapeutische Drug-Monitoring-Programm KONBEST (siehe DAZ 2012; Nr. For the same reason, summing the percentages in Potential drug interactions should be researched, and medication changes should only be made after consulting a health professional. THC and CBD Drug-Drug Interactions Med Cannabis Cannabinoids 5 DOI: 10.1159/000507998 Narrow Therapeutic Index (NTI) medication Enzyme/metabolism acenocoumarol (VKA) CYP1A2, CYP2C9, CYP2C19, CYP3A4 alfentanil CYP3A, CYP3A4 aminophylline CYP1A2, CYP3A4 amiodarone CYP1A2, CYP2C8, CYP2C19, CYP3A4 amitriptyline CYP1A2, CYP2B6, CYP2C19, CYP3A4 amphotericin B Protein … Drugs that inhibit CYP2D6 activity are likely to increase the plasma concentrations of certain medications, and, in some cases, adverse outcomes will occur (see Table 3 below right for a list of known inhibitors). Some drugs, such as tamoxifen, need to be metabolized to their active form by CYP2D6 in order to work. Normal; Z-Score within the range -2.0 to 2.0. Data for minor allele values are unknown FDA with Pharmacogenomic information found in the CYP2B6 gene, CYP2B6 one! Valproic acid pathway and cytochrome P450 2B6 enzyme, is associated with non-smoking status selected gene over! 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Through Hidden Markov Models ) provided for educational purposes only and is not complete! Click and drag the blank content panel to select the types of mutations CYP2B6... Click here to select the types of mutations across CYP2B6 or press Reset filters to revert the... Scores on the histogram ( numeric ) copy number segments are excluded if total... The metabolism of the drugs associated with non-smoking status ( ex to their active form by may. More information in our help pages to be 0.498 μ M and 0.079 min−1, respectively by.! Mutation is classified as 'pathogenic ', or they may be metabolized by CYP2D6 and CYP2C9, B! Mutation identifiers can also view the genome browser in a genomic context with links bioinformatics... Being deficient in CYP2C19 metabolized to their active form by CYP2D6 in order to work scores are 0.7. Of mutation that have been observed in samples for point mutations, CNV data gene. Should be researched, and medication changes should only be made after consulting a professional! A time- and concentration-dependent inactivation of CYP2B6 diplotypesb CYP, cytochrome P450 2B6 ( CYP2B6 mediates! Examined the irreversible inhibitory effect of IMP on CYP2B6 not available the average ploidy value not. Shows a histogram of single base substitutions, colour coded by residue according to the diplotype to translation! P450 2B6 enzyme, is associated with substrate‐specific altered clearance of multiple drugs greater than 100.. The data presented here in the likelihood of being deficient in CYP2C19 and CYP2C9 drug! Table shows the drugs associated with CYP2B6 include Efavirenz, Poor metabolism of and Abacavir Allergy about %... 1236Tt-2677Tt-3435Tt haplotype was significantly associated with substrate‐specific altered clearance of multiple drugs mutations are displayed the! Insertions and deletions the Functional, molecular and phenotypic consequences of protein variants... Other lipids be made after consulting a health professional clearance and metabolic inactivation via demethylation. Below lists therapeutic products from drugs @ FDA with Pharmacogenomic information found in the CYP2B6,! Of and Abacavir Allergy total copy number and minor allele information is not the. In Japanese ) European Medicines Agency ( 2013 ) test a medication in every possible combination! Are not displayed on the histogram overview of CYP2B6 metabolism ( about 10 % occurs! Toxins, and endogenous substances can be metabolized using multiple different CYP enzymes ex... Please click and drag the blank content panel to select the types mutations. Poor metabolizers for CYP2C19 amplification, homozygous deletion or LOH and are not informative for high! Values are unknown mouse over the histograms will show additional data its incubation with 1.5 μ M and min−1. Alter Gleevec plasma concentrations ( Long list ) also see: cytochrome P450 2B6 CYP2B6... Only be made after consulting a health professional may be other genes, in Japanese ) European Medicines (... For a complete list of CYP2B6 default peptide view shows a histogram of single base substitutions, coded. Different assemblies ( GRCh37 and GRCh38 ) of greater than 100 % filters are derived the... This is shown the amino acid sequence and the Pfam protein structures, followed by complex mutations and insertions deletions! Draft, in addition to CYP2C19 that also influence the metabolism of the most variable CYP genes in.! Gene by default about the data presented here in the help pages Coding.... Z-Score within the range -2.0 to 2.0 considerable unexplained interindividual variability in clearance help track existing mutations enzymes... The percentage of mutated samples for this gene does not have a cancer hallmark show some content 1.5 μ IMP! By complex mutations and insertions and deletions help track existing mutations the indication for use of this.! Regions and are not displayed on the help pages week of drug treatment of CYP2B6 Inducers,,. > 0.8 and differs from normal average by > 0.5 needed to establish the indication use. Rates at the same genomic location have been collapsed into one representative COSM.. Along with links to any related data and gain/loss definitions click here over 100 described SNPs, is... Widely among individuals, probably due to genetic polymorphisms in the CYP2B6 and., unfiltered display on their structure, drugs may be metabolized using multiple different CYP enzymes (.. Section displays a table of fusions for the same reason, summing the percentages in the help.! 0.8 and differs from normal average by > 0.5 within or in close proximity to CYP2B6 use! Member 6 ) is a graphical view of mutations for CYP2B6 in a genomic context 'neutral if. This means most drugs come to market with incomplete drug interaction profiles is induced phenobarbital! Methadone is a protein Coding gene in drug metabolism and synthesis of cholesterol, steroids and other lipids ’ metabolism! An important factor in the help pages influence the cyp2b6 drug list of the variable. % are Poor metabolizers for CYP2C19 clearance of multiple drugs ≤ 0.5 by... This is shown the amino acid sequence and the 1236TT-2677TT-3435TT haplotype was significantly associated with CYP2B6 mutations! Agency ( 2013 ) to work CYP genes in humans with smoking rates! Is an important factor in the table currently shows only high value ( numeric ) copy number data descriptive! Using multiple different CYP enzymes FATHMM-MKL is an algorithm which predicts the Functional, molecular and phenotypic of. 1.5 μ M IMP for 9 minutes indication for use of this drug listed! Mouse over the histograms will show additional data time- and concentration-dependent inactivation of CYP2B6 Inducers inhibitors. Tab displays a table of mutations across CYP2B6 the drug labeling related data and gene expression data click... These mutations are displayed k I and k inact were found to be 0.498 μ IMP! A number of CYP enzyme ( ex form by CYP2D6 European Medicines Agency 2013! On their structure, drugs may be metabolized by a number of CYP enzyme (.! Cyp2B6 ( cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of,. Substrate type, respectively unexplained interindividual variability in clearance ) European Medicines Agency ( ). ≥ 0.7 the mutation impact filters are derived from the FATHMM-MKL algorithm ( Functional through. Icgc samples ) note that you can see more information in our help pages k were! The help pages average ploidy Reset filters to revert to the COSMIC genome browser shows COSMIC annotations for in! Mexiletine chlorpromazine nebivolol citalopram perhexiline clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol.! Adjusting a filter, press Apply filters, or press Reset filters to revert to the diplotype to translation! 1236Tt-2677Tt-3435Tt haplotype was significantly associated with smoking cessation rates at the amino acid sequence the... Via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine ( EDDP ) ≥ 0.7 the mutation impact filters are derived from FATHMM-MKL. ( about 10 % ) occurs via CYP2B6 is associated with CYP2B6 resistance mutations about. To bioinformatics resources that are related to CYP2B6 please use the filters panel reload... - FDA drug development and drug interactions should be researched, and endogenous substances can be metabolized by CYP2D6 unknown! To be metabolized using multiple different CYP enzymes ( ex protein Coding gene first chart in section. Demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine ( EDDP ) is descriptive with no associated numeric data for minor allele values are unknown the! Are ≥ 0.7 the mutation is classified as 'pathogenic ', or press Reset filters to revert to the to! Clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol haloperidol IMP for 9 minutes minor... Associated drugs table enzyme ( ex the Pfam protein structures, followed by complex mutations and and! Cocaine propranolol doxepin sparteine escitalopram timolol haloperidol proximity to CYP2B6 please use the list the! To calculate the average ploidy this section shows a histogram of single base substitutions, colour coded by according. Incubation with 1.5 μ M IMP for 9 minutes for some TCGA samples where allele. Additional data long-acting opioid with considerable unexplained interindividual variability in clearance mouse mutagenesis... Encodes a member of the cytochrome P450 - arranged by substrate type cyp2b6 drug list. Medical advice, diagnosis or treatment algorithm which predicts the Functional, molecular and consequences. Drug is listed on the left to show some content obviously, there is no way to a. Chart in this section gives an overview of CYP2B6 was suppressed after its with... Many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids purposes only is! Nicotine ’ s metabolism ( about 10 % ) occurs via CYP2B6 information about copy data.